Open Access<p>Transcriptomics Analysis of the Tumor-Inhibitory Pathways of 6-Thioguanine in MCF-7 Cells via Silencing DNMT1 Activity</p>
Author(s) -
Hao Li,
Xinglan An,
Daoyu Zhang,
Qi Li,
Nan Zhang,
Hao Yu,
Ziyi Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s236543
Subject(s) - apoptosis , mcf 7 , cell cycle , flow cytometry , gene silencing , dnmt1 , microbiology and biotechnology , cell cycle checkpoint , downregulation and upregulation , western blot , chemistry , cancer research , biology , cancer cell , gene expression , cancer , medicine , dna methylation , gene , biochemistry , human breast
6-thioguanine (6-TG), as a conventional "ancient" drug for the treatment of acute leukemia, has been proved to have extensive anti-tumor roles. This study was created to investigate the hidden function of 6-TG on the MCF-7 breast cancer cell line (ER+, PR+) and its mechanisms.