Open Access<p>miR-423 Promotes Breast Cancer Invasion by Activating NF-κB Signaling</p>
Author(s) -
Ting Dai,
Xiaohui Zhao,
Yun Li,
Lei Yu,
Yanan Li,
Xiang Zhou,
Qiyong Gong
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s236514
Subject(s) - downregulation and upregulation , breast cancer , cancer research , microrna , metastasis , medicine , cancer , gene silencing , signal transduction , nf κb , oncology , biology , gene , microbiology and biotechnology , biochemistry , inflammation
Breast cancer has become the most common malignancy among women worldwide; therefore, novel diagnostic and prognostic markers and therapeutic targets are urgently required. NF-κB signaling plays a pivotal role in enhancing breast cancer malignant phenotypes, especially cancer invasion and metastasis, which is the main cause of death in cancer patients. TNIP2, an important inhibitor of the NF-κB pathway, is known to involve a negative feedback loop of the NF-κB signaling cascade and to regulate tumor aggressiveness in various cancer types. However, the mRNA level of TNIP2 is barely altered in breast cancer; thus, the mechanism that regulates TNIP2 in breast cancer still needs to be elucidated.