Open Access<p>Inhibition of TRIM32 Induced by miR-519d Increases the Sensitivity of Colorectal Cancer Cells to Cisplatin</p>
Author(s) -
Xueliang Su,
Bangjie Wang,
Yehong Wang,
Baochun Wang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s235940
Subject(s) - cisplatin , colorectal cancer , apoptosis , cancer research , flow cytometry , western blot , cancer cell , cancer , chemistry , medicine , chemotherapy , immunology , gene , biochemistry
Colorectal cancer is a leading cause of cancer-related death in the world. Despite cisplatin is a commonly used chemotherapeutic drug for the colorectal cancer treatment, resistance of cancer cells to cisplatin restricts its clinical efficacy. It is important to explore the potential mechanisms and take strategies to sensitize colorectal cancer cells to cisplatin treatment.