Open Access<p>Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake</p>
Author(s) -
Pengcheng Zhang,
Quancheng Wang,
Zhibin Lin,
Peijun Yang,
Kefeng Dou,
Ruohan Zhang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s235667
Subject(s) - berberine , glutamine , in vivo , chemistry , western blot , cell growth , liver cancer , transporter , downregulation and upregulation , cancer cell , metabolism , glutamine synthetase , hepatocellular carcinoma , cancer , pharmacology , cancer research , microbiology and biotechnology , biochemistry , biology , medicine , amino acid , gene
Glutamine metabolism is essential for the proliferation of cancer cells. Transported by SLC1A5, a Na + dependent transporter, glutamine is absorbed for further use. Recent studies have revealed the anti-tumor effect of berberine. The present study aimed to evaluate the effect of berberine on cancer cell glutamine metabolism.