Open Access<p>A Rare Case of Moderately Differentiated Adenocarcinoma With PD-L1 Overexpression and a Heterogeneous LELC Component in the Ascending Colon</p>
Author(s) -
Hideki Nagano,
Takeshi Watanabe,
Tamotsu Togawa,
Koji Ohnishi,
Toshihisa Kimura,
Atsuo Iida,
Yasunori Sato,
Takanori Goi
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s234945
Subject(s) - medicine , lymph , ascending colon , adenocarcinoma , colorectal cancer , lymph node , pathological , pathology , immunohistochemistry , gastroenterology , cancer
Lymphoepithelioma-like carcinomas (LELCs), especially colorectal cancers (CRCs), are uncommon pathological phenotypes generally associated with poor aggressiveness and a preferable prognosis. However, PD-L1 overexpression in CRCs is associated with poor outcomes. We report a case of moderately differentiated adenocarcinoma with PD-L1 overexpression, an LELC component, and Crohn's-like lymphoid reaction (CLR) presenting with extreme locoregional aggression and complete remission with chemotherapy after noncurative excision.