Open Access<p>TUG1 Promoted Tumor Progression by Sponging miR-335-5p and Regulating CXCR4-Mediated Infiltration of Pro-Tumor Immunocytes in CTNNB1-Mutated Hepatoblastoma</p>
Author(s) -
Fujing Xie,
Lianhai Zhang,
Qing Yao,
Liyu Shan,
Jike Liu,
Nan-Hai Dong,
Jun Liang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s234819
Subject(s) - cxcr4 , cancer research , phenotype , immune system , chemokine receptor , wnt signaling pathway , chemokine , tumor microenvironment , mutation , biology , signal transduction , medicine , microbiology and biotechnology , immunology , gene , genetics
HB presents with the highest frequency of CTNNB1 mutations, resulting in activation of Wnt signaling pathway. A number of studies have demonstrated CTNNB1 mutation contributed to the development of HB. However, limited research explored the function of lncRNAs in HB with CTNNB1 mutation.