Open Access<p>Upregulation of Cullin 4B Promotes Gastric Cancer and Predicts Poor Prognosis</p>
Author(s) -
Ping Wu,
Hailong Hu,
Jinwen Li,
Wei Gong
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s234706
Subject(s) - cullin , gene knockdown , cancer research , ubiquitin ligase , cancer , immunohistochemistry , downregulation and upregulation , gene silencing , in vivo , cell growth , biology , ubiquitin , chemistry , medicine , apoptosis , immunology , gene , biochemistry , genetics
Cullin 4B (CUL4B) is a member of the cullin ubiquitin-ligase family, which participates in proteolysis. Aberrant CUL4B expression has been shown in many malignancies. This study aimed to elucidate oncogenic role of CUL4B in gastric cancer (GC).