Open Access<p>FTY720 Suppresses Liver Tumor Growth and Metastasis by Reducing Circulating Regulating T Cells and Enhancing the Anti-Tumor Effect of Rapamycin</p>
Author(s) -
Chang Xian Li,
Xinquan Yang,
Hong Wei Wang,
Xiangcheng Li,
Kevin TakPan Ng,
Chung Mau Lo,
Kwan Man
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s234394
Subject(s) - metastasis , medicine , cancer research , angiogenesis , in vivo , hepatocellular carcinoma , hepatectomy , liver tumor , hepatic stellate cell , pathology , cancer , biology , surgery , microbiology and biotechnology , resection
In this study, we aimed to study the effect of FTY720 treatment in reducing circulating Tregs level and then suppressing liver tumor metastasis after hepatectomy and I/R injury in animal models. Furthermore, we also investigated the synergistic anti-tumor effect of FTY720 combined with rapamycin on hepatocellular carcinoma.