Open Access<p>Circular RNA circHUWE1 Is Upregulated and Promotes Cell Proliferation, Migration and Invasion in Colorectal Cancer by Sponging miR-486</p>
Author(s) -
Hongyu Chen,
Xiangnan Li,
Chun-Xiang Ye,
Zhilei Chen,
Zhenjun Wang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s233338
Subject(s) - downregulation and upregulation , gene silencing , cell growth , cancer research , colorectal cancer , flow cytometry , microrna , apoptosis , lymphovascular invasion , metastasis , biology , cancer , medicine , microbiology and biotechnology , gene , biochemistry , genetics
Emerging studies have revealed that circular RNAs (circRNAs) correlate with diverse diseases including cancers. However, little is known about the functions of circRNAs in colorectal cancer (CRC). In our previous research, downregulation of hsa_circ_0140388 (circHUEW1) has been detected in CRC tissues through high-throughput sequencing. However, the underlying mechanism by which circHUWE1 regulates the proliferation and apoptosis in CRC has not been investigated.