Open Access<p>PRKD2 Promotes Progression and Chemoresistance of AML via Regulating Notch1 Pathway</p>
Author(s) -
Qian Liu,
Wei Li,
Zhe Ying,
Jimo Jian,
Shujuan Han,
Chao Liu,
Xunxun Zhu,
Daoxin Ma,
Min Ji,
Chunyan Ji
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s233234
Subject(s) - cancer research , medicine , chemistry
Progression and chemoresistance of acute myeloid leukemia (AML) contribute to most of the treatment failure. Notch pathway has been proven to be involved in many biological processes and diseases, especially AML. In this study, we aimed to explore genes correlated with Notch1 pathway in AML and determine their roles in the regulation of AML progression and chemoresistance.