Open Access<p>Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy</p>
Author(s) -
ZhiZhou Shi,
Ze-Wen Fan,
Yunxia Chen,
Xiufeng Xie,
Wen Jiang,
Wenjun Wang,
Yuntan Qiu,
Jie Bai
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s232852
Subject(s) - gpx4 , reactive oxygen species , lipid peroxidation , autophagy , cancer research , programmed cell death , chemistry , biology , microbiology and biotechnology , glutathione , glutathione peroxidase , biochemistry , oxidative stress , apoptosis , enzyme
Ferroptosis is a new form of programmed cell death with characteristic accumulation of reactive oxygen species (ROS) resulting from iron accumulation and lipid peroxidation. Ferroptosis is involved in many diseases, including cancer, and induction of ferroptosis has shown attractive antitumour activities. In this review, we summarize recent findings on the regulatory mechanisms of key regulators of ferroptosis, including the catalytic subunit solute carrier family 7 member 11 (SLC7A11), the glutathione peroxidase 4 (GPX4), p53 and non-coding RNAs, the correlations between ferroptosis and iron homeostasis or autophagy, ferroptosis-inducing agents and nanomaterials and the diagnostic and prognostic value of ferroptosis-associated genes in TCGA data.