Open Access<p>Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells</p>
Author(s) -
Quan Yuan,
Honghao Yu,
Jianhua Chen,
Xiaoyu Song,
Li Sun
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s232718
Subject(s) - pkm2 , cancer research , osteosarcoma , downregulation and upregulation , cyclin d1 , carcinogenesis , cell growth , microrna , apoptosis , chemistry , biology , microbiology and biotechnology , cell cycle , medicine , cancer , pyruvate kinase , biochemistry , glycolysis , gene , enzyme
MicroRNAs (miRNAs) can act as negative regulators of gene expression, and play a crucial role in cancer progression. The aim of this study was to investigate the role of miR-1294/pyruvate kinase M2 (PKM2) axis in osteosarcoma cells in vitro and in vivo.