Open Access<p>Noscapine Induces Apoptosis in Human Colon Cancer Cells by Regulating Mitochondrial Damage and Warburg Effect via PTEN/PI3K/mTOR Signaling Pathway</p>
Author(s) -
Tian Xia,
Meng Li,
Xiaodong Huang,
Qingxi Zhu,
Weijie Liu,
Wei Chen,
Yanli Zou,
Yishan Cai,
Shasha Huang,
Aifang Chen,
Ting Zhan,
Min Huang,
Xiaoli Chen,
Han Zheng,
Jie Tan
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s232137
Subject(s) - noscapine , warburg effect , mitochondrial permeability transition pore , chemistry , apoptosis , mitochondrion , pi3k/akt/mtor pathway , lactate dehydrogenase , cancer cell , cancer research , microbiology and biotechnology , programmed cell death , biology , biochemistry , glycolysis , cancer , metabolism , alkaloid , genetics , stereochemistry , enzyme
Noscapine is an opium alkaloid that has recently been shown to potentiate anti-cancer therapeutic effects by inducing apoptosis in various malignant cells without any detectable toxicity. However, the mechanism by which noscapine induces apoptosis in colon cancer cells remains unclear.