Open Access<p><em>DUXAP8</em> a Pan-Cancer Prognostic Marker Involved in the Molecular Regulatory Mechanism in Hepatocellular Carcinoma: A Comprehensive Study Based on Data Mining, Bioinformatics, and in vitro Validation</p>
Author(s) -
Chaosen Yue,
Chaojie Liang,
Pengyang Li,
Lijun Yan,
Dongxin Zhang,
Xu Yang,
Zhigang Wei,
Jixiang Wu
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s231750
Subject(s) - downregulation and upregulation , cell growth , cancer research , biology , hepatocellular carcinoma , cancer , cell cycle , regulator , cell culture , biomarker , cell , oncology , medicine , bioinformatics , gene , genetics
Double homeobox A pseudogene 8 ( DUXAP8 ) has been identified as a key regulator at the posttranscriptional level in various types of cancers. However, whether DUXAP8 has a role in hepatocellular carcinoma (HCC) progression remains to be determined. Here, we aimed to investigate the potential clinical value of DUXAP8 as a pan-cancer marker, and its role in HCC development through an integrated analysis strategy and in vitro experimental validation.