Open Access<p>The Ectopic Expression of SurvivinT34A and FilC Can Enhance the Oncolytic Effects of Vaccinia Virus in Murine Gastric Cancer</p>
Author(s) -
Minglong Wang,
Yanxi Luo,
Ting Sun,
Chenyu Mao,
Yili Jiang,
Xiaofei Yu,
Zhongqi Li,
Tian Xie,
Fengbo Wu,
Hui Yan,
Lirong Teng
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s230902
Subject(s) - oncolytic virus , recombinant dna , spleen , vaccinia , virus , in vivo , cancer , medicine , splenocyte , cancer research , immune system , virology , immunology , biology , biochemistry , microbiology and biotechnology , gene
Anti-tumor vaccines have been shown to be effective in cancer therapeutics ever since the anti-HPV vaccine was developed. Compared to conventional chemotherapy, anti-tumor vaccines can specifically target cancer cells and they have lower side effects. We developed a recombinant vaccinia virus (VACV) (Western Reserve) WR strain, and we tested its anti-tumor effects in an animal model.