Open Access<p><em>Helicobacter pylori</em> CagA Protein Attenuates 5-Fu Sensitivity of Gastric Cancer Cells Through Upregulating Cellular Glucose Metabolism</p>
Author(s) -
Sujie Gao,
Defeng Song,
Yiting Liu,
Hongwei Yan,
Xuebo Chen
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s230875
Subject(s) - caga , helicobacter pylori , medicine , cancer , cancer research , chemistry , biochemistry , gene , virulence
Gastric cancer (GC) is one of the most malignancies leading to human mortality due to its development, progress, metastasis and poor prognosis, despite the development of remarkable chemotherapy and surgery. The 5-uorouracil (5-Fu) is an effective anti-gastric cancer agent. However, a fraction of GC patients acquire 5-Fu chemoresistance.