Open Access<p>Weighted Gene Co-Expression Network Analysis Identified Cancer Cell Proliferation as a Common Phenomenon During Perineural Invasion</p>
Author(s) -
Ting Huang,
Yiwei Wang,
Zhihua Wang,
Yanmei Cui,
Xiaojiang Sun,
Yudong Wang
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s229852
Subject(s) - perineural invasion , gene co expression network , cancer , immunohistochemistry , cell cycle , biology , flow cytometry , gene , cancer research , gene expression , pathology , medicine , immunology , genetics , gene ontology
Perineural invasion (PNI) is the neoplastic invasion of nerves by cancer cells, a process that may prove to be another metastatic route besides direct invasion, lymphatic spread, and vascular dissemination. Given the increasing incidence and association with poor prognosis, revealing the pathogenesis of perineural invasion is of great importance.