Open Access<p>RCC2 Interacts with Small GTPase RalA and Regulates Cell Proliferation and Motility in Gastric Cancer</p>
Author(s) -
Pengpeng Wang,
Wang Zhang,
Lili Wang,
Wenquan Liang,
Aizhen Cai,
Yunhe Gao,
Lin Chen
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s228914
Subject(s) - gene knockdown , cell growth , cancer research , cancer , cancer cell , gtpase , cell migration , mapk/erk pathway , motility , biology , guanine nucleotide exchange factor , chemistry , cell , microbiology and biotechnology , kinase , apoptosis , biochemistry , genetics
Regulator of chromosome condensation 2 (RCC2), also known as TD-60, is associated with various human malignant cancers. RCC2 has been shown to exhibit guanine exchange factor (GEF) activity and contribute to early mitosis. However, the role and mechanism of RCC2 in gastric cancer remain unclear.