Open Access<p>Downregulation of USP34 Inhibits the Growth and Migration of Pancreatic Cancer Cells via Inhibiting the PRR11</p>
Author(s) -
Changjie Lin,
Jing Xia,
Zhiwei Gu,
Yunpeng Meng,
Dongliang Gao,
Shaohua Wei
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s228857
Subject(s) - downregulation and upregulation , gene silencing , apoptosis , cancer research , cell growth , pancreatic cancer , cell migration , transfection , annexin , chemistry , cell , mapk/erk pathway , p38 mitogen activated protein kinases , carcinogenesis , cancer , microbiology and biotechnology , cell culture , signal transduction , biology , medicine , biochemistry , genetics , gene
Pancreatic cancer (PC) is a highly lethal malignancy worldwide. Our previous study indicated that overexpression of USP34 could promote tumor growth in PC cells. Therefore, this study aimed to further investigate the role of USP34 during the tumorigenesis of PC.