Open Access<p>Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells</p>
Author(s) -
Shangyuchen Shi,
Gang Zheng,
Chunsheng Yang,
Xi Chen,
Qingran Yan,
Fan Jiang,
Xiaojie Jiang,
Yong Xin,
Guan Jiang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s228792
Subject(s) - apoptosis , flow cytometry , a431 cells , cell growth , reactive oxygen species , cancer research , microbiology and biotechnology , biology , chemistry , cell cycle , oncogene , biochemistry
Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and its incidence continues to rise yearly. Photodynamic therapy (PDT) is a non-invasive form of cancer therapy, which utilizes the combined action of a photosensitizer, light, and oxygen molecules to selectively cause cellular damage to tumor cells. Vitamin K3 (VitK3) has been shown to induce apoptosis and inhibit the growth of tumor cells in humans. The purpose of this study was to determine the effect of VitK3 and ultraviolet radiation B (UVB) on oxidative damage, proliferation and apoptosis of A431 cells.