Open Access<p>Long Noncoding RNA TP73-AS1 Modulates Medulloblastoma Progression In Vitro And In Vivo By Sponging miR-494-3p And Targeting EIF5A2</p>
Author(s) -
Bing Li,
Ming-feng Shen,
Hongwei Yao,
Xuan Chen,
Xiao Zhiqiang
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s228305
Subject(s) - medulloblastoma , gene knockdown , cancer research , flow cytometry , competing endogenous rna , biology , apoptosis , antisense rna , long non coding rna , cell growth , microbiology and biotechnology , downregulation and upregulation , rna , gene , genetics
Previous studies have shown that P73 antisense RNA 1T (non-protein coding), also known as TP73-AS1, is a long non-coding RNA (lncRNA) and involved in the development of medulloblastoma. However, the regulatory mechanism of lncRNA TP73-AS1 in medulloblastoma was still unclear, the present study was aimed to investigate the detailed functions and the mechanism of TP73-AS1 in regulation of medulloblastoma.