Open Access<p>Knockdown Of lncRNA NCK-AS1 Regulates Cisplatin Resistance Through Modulating miR-137 In Osteosarcoma Cells</p>
Author(s) -
Yi Cheng,
Xiaofei Shen,
MingHua Zheng,
Guoyou Zou,
Yixin Shen
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s228199
Subject(s) - osteosarcoma , gene knockdown , cancer research , flow cytometry , cisplatin , cell growth , chemistry , microbiology and biotechnology , biology , apoptosis , chemotherapy , biochemistry , genetics
Long non-coding RNAs (lncRNAs) have been proved to act crucial parts in the progress of human tumor. However, the role of lncRNAs in drug resistance of tumor cells remains to be further elucidated. The present study aimed to explore whether lncRNA NCK-AS1 could affect the cisplatin (DDP) resistance in human osteosarcoma cell and the underlying molecular mechanism.