Open Access<p>Metformin Inhibits Proliferation of Human Thyroid Cancer TPC-1 Cells by Decreasing LRP2 to Suppress the JNK Pathway</p>
Author(s) -
Yang He,
Lingling Cao,
Li Wang,
Lingping Liu,
Ying Huang,
Xuan Gong
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s227915
Subject(s) - metformin , apoptosis , viability assay , western blot , cancer research , medicine , cell growth , endocrinology , kinase , chemistry , pharmacology , biochemistry , gene , diabetes mellitus
To uncover the potential effect of metformin on proliferation and apoptosis of thyroid cancer TPC-1 cell line, and the underlying mechanism.