Open Access<p>MiR-195-5p Inhibits Malignant Progression of Cervical Cancer by Targeting YAP1</p>
Author(s) -
Xiaomin Liu,
Yi Zhou,
Yuping Ning,
Hui Gu,
Yuxin Tong,
Ning Wang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s227826
Subject(s) - yap1 , downregulation and upregulation , cancer research , transfection , western blot , cell growth , hela , microrna , cell migration , mtt assay , cell , medicine , chemistry , cell culture , biology , gene , transcription factor , biochemistry , genetics
Our previous studies have shown that miR-195 is reduced in cervical cancer tissues, and that upregulation of miR-195 suppressed cervical cancer cell growth and induced a cell cycle block. In this study, we aimed to further elucidate the mechanism of action between miR-195-5p and Yes-associated protein 1 (YAP1) in the malignant progression of cervical cancer.