Open Access<p>miR-939-5p Contributes to the Migration and Invasion of Pancreatic Cancer by Targeting ARHGAP4</p>
Author(s) -
Yehua Shen,
Gang Chen,
Hongsheng Gao,
Ye Li,
Liping Zhuang,
Zhiqiang Meng,
Luming Liu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s227644
Subject(s) - pancreatic cancer , carcinogenesis , cancer research , viability assay , blot , transfection , gtpase , microrna , cell migration , cancer , gentamicin protection assay , biology , cancer cell , cell , cell culture , medicine , metastasis , microbiology and biotechnology , gene , biochemistry , genetics
Rho GTPase-activating protein 4 (ARHGAP4) is a GTPase-activating protein for the small GTPases of the Rho family that is involved in tumorigenesis. We recently reported that ARHGAP4 can mediate Warburg effect and malignant phenotype of pancreatic cancer. However, the regulation of ARHGAP4 remains unclear.