Open Access<p>DNMT1 Enhances the Radiosensitivity of HPV-Positive Head and Neck Squamous Cell Carcinomas via Downregulating SMG1</p>
Author(s) -
Chunlin Zhang,
Jiaoping Mi,
Yuan Deng,
Zeyi Deng,
Dan Long,
Zhao-hui Liu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s227395
Subject(s) - radiosensitivity , head and neck squamous cell carcinoma , cancer research , dnmt1 , western blot , radiation therapy , clone (java method) , cell , repressor , methyltransferase , medicine , methylation , oncology , biology , head and neck cancer , gene expression , gene , biochemistry , genetics
Head and neck squamous cell carcinoma (HNSCC), which rank the 7th malignant tumors worldwide, is closely related to methylation and HPV infection. Ionizing radiation therapy is the main strategy for HNSCC patients in advanced stage. Previously, HPV-positive HNSCC predict better prognosis than HPV-negative HNSCCs under radiotherapy, however its molecular mechanism is unresolved. SMG1 serves as a potential tumor suppressor in various cancers, including HNSCC.