Open Access<p><em>PDHA1</em> Gene Knockout In Human Esophageal Squamous Cancer Cells Resulted In Greater Warburg Effect And Aggressive Features In Vitro And In Vivo</p>
Author(s) -
Lan Liu,
Jing Cao,
Jing Zhao,
Xiangyu Li,
Zhenhe Suo,
Huixiang Li
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s226851
Subject(s) - warburg effect , cancer research , reprogramming , cell growth , cancer cell , angiogenesis , oxidative phosphorylation , in vivo , cancer , biology , cell , endocrinology , medicine , microbiology and biotechnology , biochemistry , genetics
One of the remarkable metabolic characteristics of cancer cells is that they prefer glycolysis rather than oxidative phosphorylation (OXPHOS). Pyruvate dehydrogenase E1 alpha subunit (PDHA1) is an important prerequisite for OXPHOS. Our previous studies have shown that low level of PDHA1 protein expression in esophageal squamous cell cancer (ESCC) was correlated with poor prognosis. However, the effect of PDHA1 inhibition on metabolism and biological behavior of esophageal cancer cells remains unclear.