Open Access<p>Transcriptome Analysis Reveals Key Genes and Pathways Associated with Metastasis in Breast Cancer</p>
Author(s) -
Wei Li,
Jianling Liu,
Bin Zhang,
Qingli Bie,
Hui Qian,
Wenrong Xu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s226770
Subject(s) - kegg , metastasis , cancer research , pi3k/akt/mtor pathway , breast cancer , biology , transcriptome , signal transduction , gene knockdown , cancer , gene , gene expression , microbiology and biotechnology , genetics
Metastasis is the major cause of death in breast cancer patients. Although the strategies targeting metastasis have promoted survival, the underlying mechanisms still remain unclear. In this study, we used microarray data of primary breast tumor, tumor derived from bone and liver, and skin metastatic tissue, to identify the key genes and pathways that are involved in metastasis in breast cancer.