Open Access<p>miR-140-3p Suppresses Cell Growth And Induces Apoptosis In Colorectal Cancer By Targeting PD-L1</p>
Author(s) -
Wei Jiang,
Tao Li,
Jingjing Wang,
Ruonan Jiao,
Xiao Shi,
Xiao-Dan Huang,
Guozhong Ji
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s226465
Subject(s) - microrna , apoptosis , cancer research , cell growth , colorectal cancer , downregulation and upregulation , flow cytometry , cell culture , luciferase , biology , cell , reporter gene , microbiology and biotechnology , cancer , gene expression , transfection , gene , genetics
A variety of miRNAs have been recently reported to be abnormally expressed in colorectal cancer (CRC). A growing number of studies have demonstrated that aberrantly expressed miRNAs are closely related to the development and progression of CRC. It has been found that miR-140-3p plays a vital role in several cancers. However, its expression, roles and mechanisms in CRC are remain unknown.