Open Access<p>Inhibition of ISG15 Enhances the Anti-Cancer Effect of Trametinib in Colon Cancer Cells</p>
Author(s) -
Sheng Zhou,
Meilin Ren,
Huanji Xu,
HongWei Xiao,
Qiulin Tang,
Ming Liu
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s226395
Subject(s) - isg15 , gene knockdown , cancer research , colorectal cancer , trametinib , cancer , cancer cell , cell growth , medicine , cell culture , biology , mapk/erk pathway , signal transduction , gene , microbiology and biotechnology , ubiquitin , genetics
Colon cancer is one of the most common cancers worldwide. IFN-stimulated gene 15 (ISG15), a ubiquitin-like molecule, is strongly up-regulated by type I interferon as a crucial response to a variety of microbial and cellular stress stimuli. However, the role of ISG15 in colon cancer remains unclear.