Open Access<p>MTF2 Induces Epithelial-Mesenchymal Transition and Progression of Hepatocellular Carcinoma by Transcriptionally Activating Snail</p>
Author(s) -
Tiantian Wu,
Jun Cai,
Yang Tian,
Jianfei Chen,
Zhilei Cheng,
Changsheng Pu,
Wenzai Shi,
Xiaopeng Suo,
Xianjia Wu,
Xiaowen Dou,
Ke-Ming Zhang
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s226119
Subject(s) - epithelial–mesenchymal transition , cancer research , metastasis , carcinogenesis , snail , cell migration , transcription factor , cell growth , snai1 , downregulation and upregulation , biology , hepatocellular carcinoma , chemistry , cell , cancer , gene , ecology , biochemistry , genetics
Metal regulatory transcription factor 2 (MTF2) has been previously reported as a protein binding to the metal response element of the mouse metallothionein promoter, which is involved in chromosome inactivation and pluripotency. However, the function of MTF2 in tumor formation and progression has not yet been completely elucidated.