Open Access<p>Long Non-Coding RNA HOXA-AS2 Enhances The Malignant Biological Behaviors In Glioma By Epigenetically Regulating RND3 Expression</p>
Author(s) -
Lei Wu,
XiaoYong Zhu,
Zhenyu Song,
Di Chen,
Mengguo Guo,
Junxin Liang,
Daling Ding,
Weiguang Wang,
Dongming Yan
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s225678
Subject(s) - gene knockdown , glioma , oncogene , carcinogenesis , cancer research , gene silencing , biology , microbiology and biotechnology , flow cytometry , cell growth , long non coding rna , rna , apoptosis , cell cycle , gene , genetics
Long non-coding RNAs (LncRNAs) have been demonstrated to play a vital role in human carcinogenesis. HOXA cluster antisense RNA 2 (HOXA-AS2), a 1048-bp lncRNA located between the HOXA3 and HOXA4 genes, is identified as an oncogene in several malignancies, including glioma. However, the biological functions of HOXA-AS2 and its underlying molecular mechanisms in glioma progression remain to be investigated.