Open Access<p>miR-1269b Drives Cisplatin Resistance of Human Non-Small Cell Lung Cancer via Modulating the PTEN/PI3K/AKT Signaling Pathway</p>
Author(s) -
Yang Wu,
Wei Xiao,
Zhengrong Cai,
Shidai Jin,
Tian Liu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s225010
Subject(s) - pten , cancer research , pi3k/akt/mtor pathway , cisplatin , protein kinase b , cell growth , microrna , apoptosis , flow cytometry , mtt assay , cell , chemistry , biology , medicine , microbiology and biotechnology , chemotherapy , gene , biochemistry
MiRNAs have been reported to induce certain drug resistance in multiple solid tumors via various mechanisms. Our study aimed to investigate whether miRNA-1269b was involved in the chemoresistance and the progression of non-small cell lung cancer (NSCLC).