Open Access<p>Upregulation Of miR-153 Inhibits Triple-Negative Breast Cancer Progression By Targeting ZEB2-Mediated EMT And Contributes To Better Prognosis</p>
Author(s) -
Dongliang Shi,
Yong Li,
Li Fan,
Qun Zhao,
Bibo Tan,
Guozhong Cui
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s223598
Subject(s) - triple negative breast cancer , skbr3 , vimentin , microrna , downregulation and upregulation , epithelial–mesenchymal transition , cancer research , breast cancer , immunohistochemistry , western blot , cancer , biology , oncology , medicine , pathology , metastasis , human breast , gene , biochemistry
Triple-negative breast cancer (TNBC) is the most malignant type of breast cancer. MicroRNAs (miRs) and their corresponding molecular targets are associated with the occurrence and development of various human malignancies. However, the roles of the microRNA-153 (miR-153) and zinc finger E-box-binding homeobox 2 (ZEB2)-induced epithelial-mesenchymal transition (EMT) in TNBC and predictive effect of miR-153 on the prognosis of TNBC have not been fully elucidated.