Open Access<p>Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression</p>
Author(s) -
Yuhan Hu,
Shuai Ma,
Xiang-Nan Zhang,
Zheying Zhang,
Hui Zhu,
Yinghua Ji,
Jian Li,
Xiangyang Qian,
Yongxia Wang
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s223423
Subject(s) - cell growth , cell cycle , dna methylation , cancer research , colorectal cancer , demethylating agent , epigenetics , gene knockdown , biology , flow cytometry , cell , cancer , cell culture , microbiology and biotechnology , gene expression , gene , genetics
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Studies have demonstrated that epigenetic modifications play essential roles in the development of CRC. ADHFE1 is a differentially expressed gene that has been reported to be hypermethylated in CRC. However, the role and mechanism of ADHFE1 in the proliferation of CRC remain unclear.