Open AccessUpregulation of SHIP2 participates in the development of breast cancer via promoting Wnt/β-catenin signaling
Author(s) -
Juan Zhou,
Manman Di,
Hui Han
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s223422
Subject(s) - wnt signaling pathway , cancer research , downregulation and upregulation , carcinogenesis , catenin , gene silencing , apoptosis , cell growth , biology , chemistry , cancer , signal transduction , medicine , microbiology and biotechnology , gene , biochemistry , genetics
Src homology 2-containing inositol 5-phosphatase 2 ( SHIP2 ) gene is associated with arthrosclerosis, gastric cancer and diabetes. In this study, we revealed that overexpression of SHIP2 is closely implicated with the development of breast cancer (BC).