Open Access<p>Osteoglycin (OGN) Inhibits Cell Proliferation and Invasiveness in Breast Cancer via PI3K/Akt/mTOR Signaling Pathway</p>
Author(s) -
Tao Xu,
Rui Zhang,
Menglu Dong,
Zeyu Zhang,
Hanning Li,
Chenao Zhan,
Xingrui Li
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s222967
Subject(s) - pi3k/akt/mtor pathway , cancer research , medicine , protein kinase b , cell growth , cancer , carcinogenesis , cell migration , breast cancer , cell , signal transduction , biology , microbiology and biotechnology , genetics
Previous studies have indicated that the small leucine-rich proteoglycan (SLR) osteoglycin (OGN) is downregulated in various cancers, including squamous cervical carcinoma, gastric cancer, and colorectal adenoma, indicating that OGN is a putative tumor suppressor. However, its exact role in the pathology of human cancers, especially breast cancer (BC), is not clear.