Open Access<p>Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive Oxygen Species Generation</p>
Author(s) -
Zhenghong Liu,
Cheng-Xi Yang,
Lei Zhang,
Chao Yang,
Xiuquan Xu
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s222819
Subject(s) - baicalein , mcf 7 , apoptosis , chemistry , reactive oxygen species , scutellaria baicalensis , cancer cell , intracellular , viability assay , oxidative stress , cancer research , pharmacology , microbiology and biotechnology , biochemistry , cancer , biology , medicine , pathology , traditional chinese medicine , human breast , alternative medicine
Baicalein, a natural flavonoid derived from traditional Chinese herb Scutellaria baicalensis Georg (known as Huang Qin in Chinese), has been reported to exhibit notable antitumor activity in various cancer cells, including breast cancer. However, the detailed mechanisms underlying its induced apoptosis as a prooxidant in breast cancer cells are still unknown.