Open Access<p>Long Noncoding RNA HCP5 Regulates Pancreatic Cancer Gemcitabine (GEM) Resistance By Sponging Hsa-miR-214-3p To Target HDGF</p>
Author(s) -
Yunfei Liu,
Jiale Wang,
Dong Luo,
Xia Li,
Hongwei Zhu,
Zhiqiang Li,
Yu Xiao
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s222703
Subject(s) - gemcitabine , cancer research , long non coding rna , microrna , pancreatic cancer , non coding rna , oncology , chemistry , medicine , cancer , rna , gene , biochemistry
Gemcitabine (GEM) is one of the most widely chemotherapy drugs in PC. However, the chemotherapy resistance always occurs after a period of treatment indicating poor prognosis. lncRNA may play an essential role in PC and serve as a prognosis biomarkers in PC with GEM-resistance. In our study, we aim to investigate the role of lncRNA HCP5 in PC.