Open Access<p>ARHGAP10 Inhibits the Proliferation and Metastasis of CRC Cells via Blocking the Activity of RhoA/AKT Signaling Pathway</p>
Author(s) -
Lin Li,
Dongyu Xie,
Haina Xie,
Wei Huang,
Jingxian Zhang,
Wenye Jin,
Wenjing Jiang,
Donghao Xie
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s222564
Subject(s) - protein kinase b , pi3k/akt/mtor pathway , ly294002 , rhoa , cancer research , gene silencing , transfection , cell growth , metastasis , signal transduction , phosphorylation , chemistry , cell culture , biology , microbiology and biotechnology , medicine , cancer , gene , biochemistry , genetics
ARHGAP10 belongs to the ARHGAP family, which is downregulated in certain human tumors. However, the detailed function of ARHGAP10 remains unclear in human colon carcinoma (CRC). In the current study, we aimed to explore the role of ARHGAP10 in the growth and metastasis of CRC cells.