Open Access<p>Upregulation Of miR-149-3p Suppresses Spinal Chordoma Malignancy By Targeting Smad3</p>
Author(s) -
Jie Yao,
Xuejian Wu
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s222380
Subject(s) - downregulation and upregulation , chordoma , flow cytometry , cancer research , western blot , apoptosis , carcinogenesis , microrna , gene silencing , cell growth , chemistry , microbiology and biotechnology , biology , pathology , medicine , cancer , gene , biochemistry , genetics
Dysregulation of miRNAs plays an important role in the malignancy of different tumors including chordoma. Expression of miR-149-3p was earlier reported to be downregulated in chordoma tissue. However, its biological role remains to be unrevealed in chordoma, especially in spinal chordoma.