Open Access<p>GADD45a Mediated Cell Cycle Inhibition Is Regulated By P53 In Bladder Cancer</p>
Author(s) -
Namshik Han,
Fang Yuan,
Xian Peng,
Nan Liu,
Jianmin Liu,
Haiyan Zhang,
Huayong Zhang,
Kai Yao,
Yuan Gang
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s222223
Subject(s) - cell cycle , cell growth , gene knockdown , cancer research , cell cycle checkpoint , bladder cancer , flow cytometry , cell , biology , downregulation and upregulation , cell culture , microbiology and biotechnology , cancer , chemistry , gene , genetics
Bladder cancer (BC) is one of the most prevalent malignancies of the genitourinary system, yet the underlying mechanism of BC progression still remains unclear. Growth arrest and DNA damage-inducible 45 alpha (GADD45a) is a repressive gene implicated in cell cycle regulation, as well as in human cancers development. However, its role in BC remains to be determined.