Open Access<p>miR-19a Is Involved In Progression And Malignancy Of Anaplastic Thyroid Cancer Cells</p>
Author(s) -
Giovanna Calabrese,
Anna Dolcimascolo,
Giuseppe Caruso,
Stefano Forte
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s221733
Subject(s) - microrna , anaplastic thyroid cancer , cancer research , thyroid cancer , thyroid carcinoma , cancer , malignancy , cell growth , thyroid , tumor progression , medicine , transfection , biology , oncology , gene , genetics
MicroRNAs (miRNAs) are endogenous, single-stranded, non-coding RNAs acting as negative regulators of gene expression involved in a number of physiological processes. MiRNAs' expression is commonly dysregulated in many types of human tumor diseases and cancers, including thyroid cancers, and is often involved in tumor initiation and progression. miR-19a, a member of miR-17-92 cluster, has been demonstrated to promote cell growth in anaplastic thyroid cancer (ATC), the most advanced and aggressive thyroid cancer.