Open Access<p>ASH2L-Promoted <em>HOXC8</em> Gene Expression Plays a Role in Mixed Lineage Leukemia-Rearranged Acute Leukemia</p>
Author(s) -
YuJie Wu,
Lixia Li,
Lu Liu,
Sishu Zhao,
Hai-Rong Qiu,
Hui Wang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s221643
Subject(s) - h3k4me3 , chromatin immunoprecipitation , biology , microbiology and biotechnology , histone h3 , chromatin , histone , gene , epigenetics , histone methyltransferase , cancer research , gene expression , promoter , genetics
Mixed lineage leukemia (MLL) fusion protein alone exhibits poor histone lysine methyltransferase (HKMT) activity in catalyzing histone H3 Lys4 trimethylation (H3K4me3) in MLL-rearranged acute leukemia.