Open Access<p>Long Noncoding RNA RP5-833A20.1 Suppresses Tumorigenesis In Hepatocellular Carcinoma Through Akt/ERK Pathway By Targeting miR-18a-5p</p>
Author(s) -
Zili Chen,
Yihui Ma,
Yaozhen Pan,
Shi Zuo,
Haitao Zhu,
Chao Yu,
Changhao Zhu,
Chengyi Sun
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s219797
Subject(s) - long non coding rna , mapk/erk pathway , hepatocellular carcinoma , protein kinase b , cancer research , carcinogenesis , medicine , chemistry , signal transduction , biology , rna , microbiology and biotechnology , gene , cancer , biochemistry
Previous studies indicated that long noncoding RNAs (lncRNAs) played vital roles in the development and progression of hepatocellular carcinoma (HCC). Recently, downregulation of lncRNA RP5‑833A20.1 has been observed in HCC tissues. However, the underlying mechanism by which RP5‑833A20.1 regulates the proliferation and apoptosis in HCC has not been investigated. Thus, this study aimed to investigate the role of RP5‑833A20.1 in the progression of HCC.