Open Access<p>Inhibition Of Glycogen Synthase Kinase 3 Beta Suppresses The Growth And Survival Of Skull Base Chordoma Cells By Downregulating Brachyury Expression</p>
Author(s) -
Xudong Yan,
Zhiyuan Li,
Hong Li,
Pei Liu,
Zehang Zhao,
Shan Cheng,
Zhenlin Wang,
Qiuhang Zhang
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s218930
Subject(s) - brachyury , chordoma , wnt signaling pathway , cancer research , gsk 3 , gsk3b , biology , beta catenin , cell growth , signal transduction , pathology , medicine , microbiology and biotechnology , biochemistry , embryonic stem cell , gene , mesoderm
Chordomas are locally aggressive tumors arising from notochordal remnants. Brachyury, a protein coded by T-gene, is crucial for chordoma cell proliferation. The aim of this study was to evaluate the effects of glycogen synthase kinase 3 beta (GSK3β) activity on brachyury expression and on the growth and survival of skull base chordoma cells.