Open Access<p>Long Non-Coding RNA NEAT1 Promoted Hepatocellular Carcinoma Cell Proliferation and Reduced Apoptosis Through the Regulation of Let-7b-IGF-1R Axis</p>
Author(s) -
Qin Liu,
Hexian Shi,
Jianbo Yang,
Ning Jiang
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s217763
Subject(s) - hepatocellular carcinoma , apoptosis , microrna , cancer research , cell culture , cell growth , messenger rna , long non coding rna , cell , blot , biology , rna interference , real time polymerase chain reaction , rna , gene expression , gene , microbiology and biotechnology , chemistry , genetics
Long non-coding RNA nuclear-enriched abundant transcript 1 (NEAT1) is abnormally expressed in various human malignancies, including hepatocellular carcinoma (HCC). Let-7b is a miRNA with the effect of a tumor suppressor gene, and its expression level in various tumor tissues is lower than that in normal tissues. Studies have found that IGF-1R can be abnormally activated in the process of hepatocyte deterioration, and the expression level of IGF-1R in HCC is significantly up-regulated. The aim of this study was to investigate the functional mechanism of NEAT1/let-7b-IGF-1R axis in HCC.