Open Access<p>Suppressing Hedgehog signaling reverses drug resistance of refractory acute myeloid leukemia</p>
Author(s) -
Kaikai Huang,
Zhiqiang Sun,
Bingjie Ding,
Xuejie Jiang,
Zhixiang Wang,
Yujie Zhu,
Meng Fang
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s216628
Subject(s) - myeloid leukemia , hedgehog signaling pathway , cancer research , drug resistance , medicine , smoothened , hedgehog , leukemia , pharmacology , refractory (planetary science) , signal transduction , chemistry , biology , immunology , microbiology and biotechnology , astrobiology
Hedgehog (Hh) signaling is involved in the pathogenesis of tumors. By performing gene chip analysis, we predicted that Hh signaling might regulate multiple downstream pathways in acute myeloid leukemia (AML).