Open Access<p>Mutations In Thirty Hotspot Genes In Newly Diagnosed Chinese Multiple Myeloma Patients</p>
Author(s) -
Hanjie Ying,
Wen-Ming Chen,
Jingbo Wang
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s216289
Subject(s) - neuroblastoma ras viral oncogene homolog , gene , sanger sequencing , single nucleotide polymorphism , kras , genetics , biology , missense mutation , exon , microbiology and biotechnology , mutation , cancer research , genotype
In recent years, whole-genome sequencing and whole-exon sequencing have revealed the spectrum of gene mutations in multiple myeloma (MM). Gene mutations may play an important role in the pathogenesis, progression, and prognosis of this disease. On the basis of these studies, we established a box of mutations in 30 hotspot genes and analyzed the characteristics in newly diagnosed MM patients in China.