Open Access<p>MicroRNA-145 Inhibits Cell Migration and Invasion in Colorectal Cancer by Targeting TWIST</p>
Author(s) -
Xiaoxia Shen,
Honggang Jiang,
Zhiheng Chen,
Binfeng Lu,
Yi Zhu,
Jian Mao,
Kequn Chai,
Wei Chen
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s216147
Subject(s) - cell migration , gene knockdown , microrna , epithelial–mesenchymal transition , vimentin , twist transcription factor , transfection , cancer research , small interfering rna , metastasis , downregulation and upregulation , cell , colorectal cancer , cell growth , biology , chemistry , cell culture , cancer , immunology , immunohistochemistry , gene , biochemistry , genetics
MicroRNAs function as oncogenes or tumor suppressors in the development of various human cancers. We investigated the effect of microRNA-145 (miR-145) on colorectal cancer (CRC) cell invasion and migration.